4-HO-MET (4-hydroxy-N-methyl-N-ethyltryptamine), also known as metocin, is a psychedelic compound in the tryptamine class. It is structurally related to psilocin (the active compound in magic mushrooms) and shares similar effects.
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Description

Buy 4-HO-MET in the USA

The synthetic psychedelic drug 4-HO-MET, also known by its chemical name 4-hydroxy-N-methyl-N-ethyltryptamine, is a member of the tryptamine class. Similar in structure to psilocin, the main ingredient in magic mushrooms, 4-HO-MET causes psychedelic effects that are on par with those of traditional psychedelics like psilocybin or LSD. Due to its brief duration and rather modest visual impacts, it has become more and more popular among academics and psychonauts in recent years.

What Is 4-HO-MET in the USA?

The chemist Alexander Shulgin created 4-HO-MET, a synthetic tryptamine, and described it in his book TiHKAL (Tryptamines I Have Known and Loved). In terms of chemistry, it is MET’s (N-methyl-N-ethyltryptamine) 4-hydroxy analogue. A hydroxy group on the fourth position of the indole ring, which is present in many psychedelic tryptamines, is indicated by the prefix “4-HO.”

Structurally similar to psilocin, 4-HO-MET is sometimes referred to as a “synthetic shroom”, as its effects closely resemble those of magic mushrooms, albeit with subtle differences.

Effects of 4-HO-MET in the USA

4-HO-MET has a reputation for causing mild psychedelic effects, which can include both emotional and visual impacts. People looking for a milder psychedelic experience frequently choose it because most users report that the experience is less intense than that of LSD or psilocybin.

Common Effects Include:

  • Visual hallucinations: Enhanced colors, patterns, and light distortions.

  • Euphoria and emotional sensitivity.

  • Altered perception of time and space.

  • Increased creativity and introspective thoughts.

  • Mild body high and sensory enhancement.

Duration:

  • Onset: 20–40 minutes

  • Peak: 1.5–3 hours

  • Total duration: 4–6 hours

For someone who might not want to commit to a full day, as is frequently the case with LSD, 4-HO-MET’s very brief duration makes it manageable.

Dosage Guidelines

As with all psychedelics, dosage plays a critical role in the experience. Individual sensitivity, tolerance, and body weight can all affect the intensity of effects.

Common Dosage Range:

  • Threshold: 2–5 mg

  • Light dose: 5–10 mg

  • Moderate dose: 10–20 mg

  • Strong dose: 20–30 mg

  • Heavy dose: 30+ mg

It is advisable to start with a low dose to gauge personal sensitivity, especially for first-time users or those new to psychedelics.

4-HO-MET vs Psilocybin

Though chemically similar, there are notable differences between 4-HO-MET and psilocybin:

Feature 4-HO-MET Psilocybin
Duration 4–6 hours 6–8 hours
Intensity Milder Can be intense
Visuals More geometric and colorful More organic and flowing
Legality Often gray area Illegal in most countries

4-HO-MET may offer a more controlled and predictable experience compared to natural psilocybin-containing mushrooms, which can vary in potency.

Legality of 4-HO-MET

Depending on the jurisdiction, 4-HO-MET’s legal status differs significantly. Although the United Nations Convention on Psychotropic Substances does not list it, numerous nations have similar rules or specific prohibitions:

Countries Where It May Be Illegal or Controlled:

  • United States: Unscheduled federally, but may be considered illegal under the Federal Analogue Act.

  • Germany: Listed under the NpSG (New Psychoactive Substances Act).

  • United Kingdom: Class A under the Psychoactive Substances Act.

  • Sweden and Japan: Specifically scheduled.

Always check local laws before acquiring or possessing any research chemical.

Pharmacology and Mechanism of Action

4-HO-MET mostly functions as a partial agonist of the 5-HT2A receptor, which is also the receptor that gives LSD, psilocin, and DMT their psychedelic effects. It modifies mood, cognition, and sensory perception by attaching itself to serotonin receptors in the brain.

4-HO-MET is active in its original form, which results in a quicker onset and cleaner metabolism than psilocybin, which is a prodrug (converted into psilocin in the body).

 

What does 4-HO-MET feel like?

The effects of 4-HO-MET are similar to those of magic mushrooms.

Common short-term effects include:

Euphoria
Connectedness to nature
Increased awareness and consciousness
Mindfulness, being present
Music enhancement
Increased creativity and open-mindedness
Pain relief
Higher capability for love and compassion
Seeing life from a different perspective
Appreciating small things
Expanded sense of self
Feeling one with all that is
Higher energy
Stamina enhancement
Feeling your emotions more intensely
Memory suppression
Inability to sleep
Time distortion
Visual effects (enhanced colors, seeing patterns in everything, distortions, …)
Nausea, vomiting
Getting stuck in a thought loop
Inability to focus
Worse thermoregulation
Increased heart rate
Difficulty urinating
Confusion
Headache
Anxiety, paranoia
Vulnerability

The higher dose you take, the more intense these effects will be.

With that said, it is impossible to accurately describe the experience through human language.

The psychedelic affects each individual differently and no two trips are the same. Therefore, there is virtually no way to know what your trip will feel like.

The only way to truly know what 4-HO-MET feels like is to take it.

4-HO-MET will most likely give you a pleasant experience. Bad trips can happen but you can prevent them by following the tips below.

Bad trips

Bad trips mostly happen because people take the substance irresponsibly. If you take this psychedelic the right way, there is virtually no chance you’ll get a bad trip.

In case you still do, that’s good! A “bad” trip isn’t always bad, it can actually be the most healing and insightful moment of your life!

During a “bad” trip, negative emotions are coming up from your subconscious mind. They have always been there whether you are aware of it or not. They have been damaging your life and a difficult trip is an opportunity to process these traumas and unpleasant feelings and let go of them.

The more painful the experience, the more you can heal.

So instead of calling bad trips bad, call them challenging.

If you understand that bad trips are awesome in the long run, not only will you feel more comfortable diving into these challenging states, it will actually excite you!

Why they happen

The most common reasons for getting a bad trip are:

  • Tripping in an unsafe environment (in public, at a party, even nature doesn’t feel safe if you take higher doses)
  • Facing difficult times in your day-to-day life (a break-up, death of a loved one, …)
  • Rejecting to let go and trying to hold on to your ego and control the state
  • Being afraid of the trip (either because of the stigma around psychedelics or because you are not sure how pure your substance is)
  • Mixing the psychedelic with alcohol, weed, or other drugs
  • Expecting a bad trip (it can easily become a self-fulfilling prophecy)

How to cope with a bad trip

  • Do not perceive this experience as something bad, remember that facing these difficult emotions is extremely healing
  • Fully surrender to the experience, do not try to feel good
  • If you’re alone, call a trusted friend to come over and keep you safe

How to end a bad trip

In case you are not ready to face your inner demons yet, there are a few ways to end a bad trip.

One possible way is to put on music that is familiar to you. Another way is to switch up your location and move from one place to another. This can completely change your train of thought.

In case the trip becomes extremely challenging and there is no one around you to keep you safe, consider ending your trip with a trip killer.

Using a trip killer usually is not the best idea because the bad emotions will stay unresolved and you will get little to no benefits from the experience. With that said, using a trip killer is smarter than harming yourself.

The 2 best options that you have for ending a bad trip are Phenibut and benzodiazepines. Phenibut is generally safer but it can take a few hours to kick in and end your trip.

So to end a trip, use benzodiazepines. But again, only do it if there is no other way.

Interactions

  • Qualia Mind
    This nootropic is comprised of 28 ingredients designed to support and maximize your brain function. These ingredients act synergistically and many of them will protect you from the potential neurotoxic effects of the psychedelic. Qualia will also make your trips more pleasant and help you retain more benefits from them.
  • Lion’s Mane and Niacin
    Taking Lion’s mane and niacin combined with a microdose of psilocybin or other serotonergic psychedelics can result in significant improvements in neuroplasticity. This combination is also called the “Paul Stamets Stack,” as it was developed by Paul Stamets, a leading expert in mycology. Specifically, Paul recommends taking a microdose with 1 gram of dry Lion’s mane and 50-100 mg of niacin every 3rd day.
  • Ginger
    Ginger significantly reduces nausea and can prevent you from vomiting.
  • Herbs
    Along with ginger, other herbs can help you reduce nausea as well. They can also help you calm down. Herbal teas (chamomile, lemon balm, valerian root, …) are especially helpful.
  • Green tea
    Tea makes you both more alert and calm at the same time. It also contains neuroprotective antioxidants, such as EGCG.
  • CBD
    CBD has a calming effect.
  • LSD
    These substances act synergistically, some people prefer this combination instead of taking the two individually.
  • Weed
    Marijuana will intensify your trip. If you combine these substances, marijuana will also become more psychedelic for you.
  • MDMA
    These drugs have a synergistic effect but tryptamines might increase the neurotoxicity of MDMA. Also, do not combine the two if you suffer from heart problems.
  • Nitrous oxide
    Nitrous oxide will multiply the intensity of your trip.
  • Dissociatives
    Combining dissociatives with psychedelics won’t necessarily cause you harm but it can be confusing and lead to bad trips.
  • Benzodiazepines (Valium, Xanax, …)
    Benzos will end your psychedelic experience within 40 minutes but using this method may cause you side effects in the long run.
  • Alcohol
    Alcohol minimizes all the potential benefits of a psychedelic experience. It also greatly increases your chance of having a bad trip.
  • SSRIs or MAOIs
    Not only will these antidepressants greatly decrease the intensity of your trip, but they can also lead to long-lasting side effects.
  • Lithium
    Combining psychedelics with lithium significantly increases the risk of seizures and psychosis.
  • Stimulants
    The combination can easily lead to heart problems, even if you’re a healthy individual.
  • Tramadol
    Combining the two can cause seizures.
  • St. John’s Wort
    This combination may lead to serotonin syndrome.

Microdosing

The effects of microdosing 4-HO-MET are not well-known but since the substance is extremely similar to psilocybin mushrooms, microdosing 4-HO-MET should be almost identical to microdosing shrooms.

If you are not ready to take higher doses, microdosing is a way to go because it can bring similar benefits to your life with even fewer side effects.

Experts in the field generally recommend microdosing every 3rd day. Taking a microdose more often is not a good idea because you would become tolerant to psilocybin and the substance would have little to no effect.

Around 80% of people who take microdoses claim that it has profoundly changed their lives.

For some, microdosing has cured their depression and helped them find beauty in small things. Some also say that they experience significantly less anxiety when they microdose.

Many people take tiny doses of mushrooms to become more creative and productive throughout the day. Microdosing has also been shown to increase athletic performance.

What is awesome about microdosing is that you can stop at any time in case you notice some adverse reaction or if you simply don’t see any benefits.

FAQ

Becoming addicted to the substance is virtually impossible. What you need to know about is tolerance.

If you were to trip 2 days in a row, your 2nd trip would be extremely weak. You will have to wait for several days to refresh your tolerance.

How many days does it take?

This mostly depends on the dose. At regular doses, it takes approximately 7 days to become sensitive again.

So you could technically take the drug every week but if you want to maximize the benefits, do not trip before you integrate all the lessons from your last trip.

Counter-intuitively, you might get more benefits by tripping less often.

That is why you may only want to trip once or twice a month or just a couple of times a year.

As your trips get more and more intense, you will not want to trip nearly as often anyway.

Psilocin’s psychedelic effects are believed to come from its agonist activity on serotonin 5-HT2A/C and 5-HT1A receptors.

Unlike LSD, psilocin has no significant effect on dopamine receptors and only affects the noradrenergic system at very high dosages.

Psilocybin has also been shown by fMRI imaging to have a dampening effect on certain brain regions, most notably the Default Mode Network.

With that said, the only way to truly know what this psychedelic does to your brain is to try it yourself.

Most importantly, you need to trip in a safe place where you feel comfortable.

Whether you should take the drug at home or in nature will depend on your priorities.

Tripping at home is safer and probably better for personal growth while taking the substance outside will help you develop a strong connection with nature.

Try both and see which one you like more.

If you are a mentally stable individual who does not suffer from psychosis or have a predisposition to schizophrenia, there is virtually no way you would develop any mental illnesses because of this psychedelic.

4-HO-MET isn’t easy to detect in your saliva or blood.

Some special tests could technically detect that you’ve taken the drug but the policemen don’t use such tests.

Even on these special tests, the drug cannot be detected after 24 hours since you’ve taken it.

Keep the powder in a cold dark place, preferably with no air.

If you don’t do this, the drug will lose potency within a few weeks or months.

When you store the substance well, it will last for over a year.

In psilocybin psychotherapy, patients are encouraged to eat a light, low-fat breakfast 1 or 2 hours before taking the substance.

Eating before you trip on psilocybin-like tryptamines has some advantages as well as a few disadvantages.

One reason you’d want to eat before your trip is because people sometimes lose appetite on psychedelics.

Preparing and eating food can also be a distraction.

If you don’t eat anything and become hungry during your trip, it can make you feel fatigued and irritated.

However, eating before taking the psychedelic can cause nausea and even make you vomit.

The substance will also take longer to kick in, sometimes up to 2 hours.

So the best way to go about food is to eat a little bit 1-2 hours before the trip and have some snacks prepared next to you.

Conclusion

4-HO-MET is an intriguing substance that falls midway between natural psychedelics and synthetic innovation. With effects similar to magic mushrooms but with a shorter duration and more controllable intensity, it has earned a place among the most popular study substances in the psychedelic world.

However, the potential for psychological anguish, paucity of clinical research, and legal dangers underscore the significance of harm reduction and responsible use. You must be well-prepared and knowledgeable if you plan to experiment with 4-HO-MET.

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